Home stimulation, development, and nutritional status of children under 2 years of age in the highlands of Madagascar.

BACKGROUND: The Vakinankaratra region of Madagascar has a high burden of child undernutrition which, in addition to poor psychosocial stimulation, is a strong risk factor of poor child development. However, there are limited studies evaluating the relations between developmental deficits, child nutrition outcomes, and home stimulation in the region. The purpose of this study was to assess the development of children aged 11-13 months in relation to their nutritional status and to examine parental home stimulation attitudes and practices in the Vakinankaratra region. METHODS: Cognitive (n = 36), language (n = 36), motor (n = 36), and socioemotional (n = 76) development were assessed using the Bayley Scales of Infant and Toddler Development III. Household stimulation environment was evaluated using the family care indicators survey. Stunting (length-for-age z-score < - 2) and underweight (weight-for-age z-score < - 2) were determined using the 2006 WHO growth standards. Perceptions of and barriers to greater home stimulation for children were collected using focus group discussions among parents and in-depth interviews with community nutrition agents. RESULTS: Almost all mothers reported that parent-child interaction with talk and play was very important. Alarmingly high stunting rates (> 69%) were observed in this subsample. Limited time and tiredness were the major barriers to home stimulation mentioned by parents and confirmed by key informants. Children had a very limited variety of play materials, and most of the mothers used household objects (75%) and materials from outside the house (71%) as children's toys. Composite cognitive [mean (SD): 60 (10.3)], motor [61.9 (13.4)], language [62 (13.2)], and socioemotional [85.1 (17.9]) scores were low. Fine motor, cognitive, and receptive and expressive language scores were correlated [0.4 < r < 0.7, p < 0.05]. CONCLUSIONS: The very high stunting rates and very low performance on cognitive, motor, language, and socioemotional development assessments of children in the Vakinankaratra region require urgent attention.

Risk factors for early occurrence of malnutrition in infants with severe congenital heart disease.

To identify the risk factors of early occurrence of malnutrition in infants with severe congenital heart disease (CHD) during their first year of life. Retrospective longitudinal multicenter study carried out from January 2014 to December 2020 in two tertiary care CHD centers. Four CHD hemodynamic groups were identified. Malnutrition was defined by a Waterlow score under 80% and/or underweight under -2 standard deviations. A total of 216 infants with a severe CHD, e.g., requiring cardiac surgery, cardiac catheterization, or hospitalization for heart failure during their first year of life, were included in the study. Malnutrition was observed among 43% of the cohort, with the highest prevalence in infants with increased pulmonary blood flow (71%) compared to the other hemodynamic groups (p < 0.001). In multivariate analysis, low birthweight (OR 0.62, 95% CI 0.44-0.89, p = 0.009), CHD with increased pulmonary blood flow (OR 4.80, 95% CI 1.42-16.20, p = 0.08), heart failure (OR 9.26, 95% CI 4.04-21.25, p < 0.001), and the number of hospitalizations (OR 1.35, 95% CI 1.08 l-1.69, p = 0.009) during the first year of life were associated with malnutrition (AUC 0.85, 95% CI 0.79-0.90).  Conclusions: In infants with a severe CHD, early occurrence of malnutrition during the first year of life affected a high proportion of subjects. CHD with increased pulmonary blood flow, low birthweight, heart failure, and repeated hospitalizations were risk factors for malnutrition. Further studies are required to identify optimal nutritional support in this population. What is Known: • Malnutrition is a known morbidity and mortality factor in children with severe congenital heart disease. What is New: • Early occurrence of malnutrition during the first year of life in infant severe congenital heart disease (CHD) was high (43%). • CHD with increased pulmonary blood flow, low birthweight, heart failure, and repeated hospitalizations during the first year of life were risk factors for malnutrition.

Infant Nutrition in Low- and Middle-Income Countries.

The burden of infant malnutrition is greatest in low- and middle-income countries (LMICs). Infant malnutrition is defined based on distinct subcategories, among them stunting (low-height-for-age) and wasting (low-weight-for-height). Some experts are shifting more toward understanding the interplay between these overlapping phenotypes and other confounding factors such as maternal nutrition and environmental hygiene. Current guidelines emphasize appropriate breastfeeding and nutrition within the 1000 days from conception to a child's second birthday to optimize early development. Future research directed toward better biomarkers of malnutrition before acute clinical symptoms develop will help direct targeted efforts toward at-risk populations.

La desnutrición infantil en Ecuador. Una revisión de literatura / Child malnutrition in Ecuador. A literature review

La desnutrición infantil constituye un grave problema de salud, afectando los sectores sociales más desfavorecidos. La desnutrición causa disminución del crecimiento y del desempeño escolar, altera el estado bioquímico e incrementa la morbimortalidad infantil. Entre las principales causas de desnutrición están la dieta inadecuada, la presencia de infecciones que interfieren con la utilización adecuada de nutrientes, inequidad e insuficiente disponibilidad de alimentos. En América Latina, aproximadamente 2,3 millones de niños de 0 a 4 años se ven afectados por desnutrición moderada o grave y 8,8 millones presentan baja talla para su edad, con alta prevalencia de desnutrición crónica, lo que es atribuible a determinantes sociales, económicos y políticas de salud deficientes en la mayoría de países de la región. En Ecuador existe una prevalencia de desnutrición de 23,2%, situación que se agrava en el contexto rural, presentando más frecuencia en la Sierra (32%), la Costa (15,7%), la Amazonía (22,7%) y la zona Insular (5,8%), y aun cuando se han implementado programas de nutrición, los logros positivos de indicadores nutricionales, no han alcanzado impactar lo suficiente en algunas comunidades indígenas en las que se estima una tasa de desnutrición crónica infantil por encima de 50%. La presente investigación muestra los principales rasgos de la desnutrición infantil en Ecuador, partiendo de un diseño cualitativo, interpretativo y análisis documental con el objetivo de sistematizar el conocimiento y fortalecer las bases teórico-metodológicas de planes y estrategias necesarios para disminuir los efectos negativos de la desnutrición en el desarrollo infantil(AU)

Infant malnutrition constitutes a serious health problem, affecting the most disadvantaged social sectors. Malnutrition causes a decrease in growth and school performance, an alteration in the biochemical state and an increase in infant morbidity and mortality. Among the main causes of malnutrition are an inadequate diet, the presence of infections that interfere with the adequate use of nutrients, inequity, and insufficient food availability. In Latin America, approximately 2.3 million children aged 0 to 4 are affected by moderate or severe malnutrition and 8.8 million are short for their age, with a high prevalence of chronic malnutrition, which is attributable to social determinants economic, economic and health policies in most countries of the region. In Ecuador there is a prevalence of malnutrition of 23.2%, a situation that worsens in the rural context, presenting more frequency in the Sierra (32%), the Coast (15.7%), the Amazon (22.7%) and the Insular zone (5.8%), and even when nutrition programs have been implemented, the positive achievements of nutritional indicators have not had a sufficient impact on some indigenous communities in which a rate of chronic child malnutrition is estimated by above 50%. This research shows the main features of child malnutrition in Ecuador, starting from a qualitative, interpretive design and documentary analysis with the aim of systematizing knowledge and strengthening the theoretical-methodological bases of plans and strategies necessary to reduce the negative effects of the malnutrition in child development(AU)

Use of TaqMan Array Cards to investigate the aetiological agents of diarrhoea among young infants with severe acute malnutrition.

OBJECTIVE: Studies involving less sensitive conventional microscopy and culture-based approaches have identified distinct differences in diarrhoeal aetiology in childhood malnutrition. Our study involved the use of an advanced molecular biology technique, the TaqMan Array Cards (TAC), to elucidate the diarrhoeal aetiology among young infants with severe acute malnutrition (SAM). METHOD: A total of 113 faecal samples was collected from SAM infants, aged 2-6 months, upon admission to the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) with complications of diarrhoea and related comorbidities. We used TAC for the detection of 29 different diarrhoeal enteropathogens from a single faecal sample. For comparison, we also analysed 25 diarrhoeal samples from well-nourished infants of similar age. RESULTS: Higher odds of detection of all bacterial enteropathogens were associated with diarrhoea among SAM infants. In particular, the detection of Aeromonas sp (aOR: 25.7, p = 0.011), Campylobacter sp (aOR: 9.6, p < 0.01) and ETEC (aOR: 5.2, p = 0.022) was significantly associated with diarrhoea among SAM infants in comparison to well-nourished infants. 80% higher odds of detection of rotavirus and norovirus GII were associated with diarrhoea among well-nourished infants in comparison to SAM infants (aOR: 0.2, p < 0.05). CONCLUSION: Our study findings demonstrate a difference in diarrhoeal aetiology among SAM and well-nourished young infants, which may be useful in providing an evidence-based logic for possible revision of treatment guidelines for treatment of young diarrhoeal infants with SAM in the early management of the menace of antimicrobial resistance.

Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study.

BACKGROUND: Malnutrition in early life may affect health in later life. The associations between malnutrition and serum uric acid (SUA) and hypertension were inconsistent. The present study aimed to investigate the individual and combined association between famine exposure and serum uric acid and hypertension in middle-aged and older Chinese. METHODS: Data were selected from the China Health and Retirement Longitudinal Study (CHARLS) Wave2011. The analytic sample included 9368 individuals aged 45 to 90. Differences between baseline characteristics and famine exposure/SUA level were evaluated using the Chi-square test, t-test, and F-test. Then, the differences in the prevalence of hypertension between characteristic groups was also estimated by the Chi-square and t-test. Finally, multivariable-adjusted logistic regression models examined association of famine exposure and serum uric acid with odds of prevalence of hypertension. RESULTS: A total of 9368 individuals were enrolled in the study, 4366 (46.61%) and 5002 (53.39%) were male and female, respectively. Among males, 459 (10.51%) had been exposed to the Chinese famine during the fetal stage, whereas 1760 (40.31%) and 1645 (37.68%) had been exposed to the famine during childhood and adolescence/adult stage, respectively. Among females, 635 (12.69%) had been exposed to the Chinese famine during the fetal stage, whereas 1988 (39.74%) and 1569 (31.37%) had been exposed to the famine during childhood and adolescence/adult stage, respectively. Regarding the participants with SUA level measurements, 290 (6.64%) reported having Hyperuricemia (HUA) in males and 234 (4.68%) in the females. Furthermore, 1357 (31.08%) reported having hypertension in male and 1619 (32.37%) in the female. In multivariable-adjusted model, famine exposure and serum uric acid were associated with prevalence of hypertension independently in total populations [(1) Model fourd, fatal exposed group vs non-exposed group: 1.25 (95% CI 1.03, 1.52); childhood-exposed group vs non-exposed group:1.60 (95% CI 1.37, 1.87); adolescence/adult exposed group vs non-exposed group: 2.87 (95% CI 2.44, 3.37), P for trend < 0.001; (2) Model four e, high vs normal:1.73 (95% CI 1.44, 2.08)]. When stratified by sex, the results in both males and females were similar to those in the total population. In general, interaction analysis in the multivariable-adjusted model, compared with the combination of normal SUA level and no-exposed famine stage, all groups trended towards higher odds of prevalence of hypertension [the greatest increase in odds, adolescence/adult exposed stage and high SUA level in total participants: OR4.34; 95%CI 3.24, 5.81; P for interaction < 0.001]. When stratified by sex, the results in both males and females were also similar to those in the total population. CONCLUSION: Our data support a strongly positive individual and combined association of famine exposure and serum uric acid with hypertension in middle-aged and elderly Chinese.

Malnutrition in Infants Aged under 6 Months Attending Community Health Centres: A Cross Sectional Survey.

A poor understanding of malnutrition burden is a common reason for not prioritizing the care of small and nutritionally at-risk infants aged under-six months (infants u6m). We aimed to estimate the anthropometric deficit prevalence in infants u6m attending health centres, using the Composite Index of Anthropometric Failure (CIAF), and to assess the overlap of different individual indicators. We undertook a two-week survey of all infants u6m visiting 18 health centres in two zones of the Oromia region, Ethiopia. We measured weight, length, and MUAC (mid-upper arm circumference) and calculated weight-for-length (WLZ), length-for-age (LAZ), and weight-for-age z-scores (WAZ). Overall, 21.7% (95% CI: 19.2; 24.3) of infants u6m presented CIAF, and of these, 10.7% (95% CI: 8.93; 12.7) had multiple anthropometric deficits. Low MUAC overlapped with 47.5% (95% CI: 38.0; 57.3), 43.8% (95% CI: 34.9; 53.1), and 42.6% (95% CI: 36.3; 49.2) of the stunted, wasted, and CIAF prevalence, respectively. Underweight overlapped with 63.4% (95% CI: 53.6; 72.2), 52.7% (95% CI: 43.4; 61.7), and 59.6% (95% CI: 53.1; 65.9) of the stunted, wasted, and CIAF prevalence, respectively. Anthropometric deficits, single and multiple, are prevalent in infants attending health centres. WAZ overlaps more with other forms of anthropometric deficits than MUAC.

Complementary Foods and Milk-Based Formulas Provide Excess Protein but Suboptimal Key Micronutrients and Essential Fatty Acids in the Intakes of Infants and Toddlers from Urban Settings in Malaysia.

This study determined the intakes of complementary foods (CFs) and milk-based formulas (MFs) by a total of 119 subjects aged 6-23.9 months from urban day care centers. Dietary intakes were assessed using two-day weighed food records. Intake adequacy of energy and nutrients was compared to the Recommended Nutrient Intakes (RNI) for Malaysia. The most commonly consumed CFs were cereals (rice, noodles, bread). The subjects derived approximately half of their energy requirements (kcals) from CFs (57 ± 35%) and MFs (56 ± 31%). Protein intake was in excess of their RNI requirements, from both CFs (145 ± 72%) and MFs (133 ± 88%). Main sources of protein included meat, dairy products, and western fast food. Intake of CFs provided less than the RNI requirements for vitamin A, thiamine, riboflavin, folate, vitamin C, calcium, iron, and zinc. Neither CF nor MF intake met the Adequate Intake (AI) requirements for essential fatty acids. These findings indicate imbalances in the dietary intake of the subjects that may have adverse health implications, including increased risk of rapid weight gain from excess protein intake, and linear growth faltering and intellectual impairment from multiple micronutrient deficiencies. Interventions are needed to improve child feeding knowledge and practices among parents and child care providers.

Infant malnutrition treatment in Kenya: Health worker and breastfeeding peer supporter experiences.

Acute malnutrition in infants under 6 months (u6m) is increasingly recognised as a global public health problem. The World Health Organisation (WHO) guidelines for inpatient nutritional rehabilitation of infants u6m is re-lactation: the re-establishment of exclusive breastfeeding. Evidence suggests these guidelines are rarely followed in many low-income settings. Two studies of infant nutritional rehabilitation undertaken in three public hospitals in coastal Kenya employed breastfeeding peer supporters (BFPSs) to facilitate WHO guideline implementation. To explore the acceptability of the strategy to health workers (HWs) and the BFPSs, in-depth interviews were conducted with 20 HWs and five BFPSs in the three study hospitals. The HWs reported that the presence of the BFPSs changed the way infant nutritional rehabilitation was managed, increasing efforts at relactation and decreasing reliance on supplemental milk. BFPSs were said to help address staff shortages and had dedicated time to support and assist the mothers. Key to the success of the BFPSs was the social relationships they were able to establish with the mothers due to the similarity in their experiences and backgrounds. Despite the success of the BFPSs, human resource management and infrastructure challenges remained. BFPSs can successfully be employed to facilitate the implementation of the WHO guidelines for the nutritional rehabilitation of acutely malnourished infants u6m in hospitals in Kenya, establishing supportive social relationships and trust with the mothers of the acutely malnourished infants and helping to address the issue of human resource shortages.

Estado nutricional de niños menores de 6 meses de edad en un centro hospitalario pediátrico de Perú: prevalencia y factores asociados / Nutritional status of children under 6 months of age in a pediatric hospital in Peru: prevalence and associated factors

Introducción: La desnutrición en los primeros meses de vida puede ser superior y más crítica que una posible malnutrición en años posteriores. A pesar de la previa documentación de esta realidad, la evaluación nutricional no está contemplada como método rutinario y riguroso al momento de admisión, estancia y egreso del paciente en los hospitales públicos y privados. Objetivo: Describir la prevalencia y factores asociados al estado nutricional de niños menores de 6 meses de edad hospitalizados en los servicios de medicina del Instituto Nacional de Salud del Niño de Perú. Material y métodos: Estudio retrospectivo y transversal en niños menores de 6 meses de edad hospitalizados en los servicios de medicina del INSN durante el año 2017. Se excluyeron aquellos con malformación congénita, trastorno genético, infección por VIH o con diagnóstico de neoplasia maligna, con ascitis, anasarca, o edemas. Se realizó un censo de pacientes hospitalizados tomando como referencia los egresos hospitalarios del año 2017, se logró una muestra total de 284 lactantes hospitalizados que cumplieron los criterios de inclusión del estudio. Resultados: La prevalencia de desnutrición aguda fue de 8,5%, desnutrición global de 9,2% y desnutrición crónica de 8,8%, sobrepeso de 7,7% y obesidad 6,7%. Conclusión: Según el análisis multivariado se pudo determinar una asociación entre el peso al nacer, la edad y la procedencia con la desnutrición global; la estancia hospitalaria, la presencia de anemia y la edad con la desnutrición aguda; y el peso al nacer, con la desnutrición crónica. (U)

Introduction: Malnutrition in the first months of life can be higher and more critical than possible malnutrition in later years. Despite previous documentation of this reality, nutritional evaluation is not considered as a routine and rigorous method at the time of admission, stay and discharge of the patient in public and private hospitals. Objective: To describe the prevalence and factors associated with the nutritional status of children under 6 months of age hospitalized in the medicine services of the National Institute of Child Health of Peru. Material and methods: Retrospective and cross-sectional study in children under 6 months of age hospitalized in the INSN medicine services during 2017. Those with congenital malformation, genetic disorder, HIV infection or with a diagnosis of malignant neoplasia, with ascites, anasarca, edema. A census of hospitalized patients was carried out taking as a reference the hospital discharges of the year 2017, a total sample of 284 hospitalized infants was obtained who met the inclusion criteria of the study. Results: The prevalence of acute malnutrition was 8.5%, global malnutrition 9.2% and chronic malnutrition of 8.8%, overweight of 7.7% and obesity 6.7%. Conclusion: According to the multivariate analysis, an association between birth weight, age and origin with global malnutrition could be determined; hospital stay, presence of anemia and age with acute malnutrition; and birth weight, with chronic malnutrition. (AU)

Evaluación nutricional de niños de uno a tres años en la Parroquia de Calderón en Quito / Nutritional assessment of children between one and three years in the Calderón parish of the city of Quito

OBJETIVO: Evaluar la situación nutricional de los niños de uno a tres años en los centros de desarrollo infantil en la parroquia de Calderón. MATERIALES Y MÉTODOS: Estudio descriptivo de corte transversal en 646 niños de uno a tres años que asisten regularmente a veinte centros de desarrollo infantil en la parroquia de Calderón de la ciudad de Quito: el 51,2 % niños y el 48,8 % niñas. Para esto, se tomó como dimensión temporal un estudio comprendido entre el período de mayo a septiembre de 2019. Se describieron las variables en promedio, desviación estándar, con un análisis comparativo por sexo. RESULTADOS: Se determinó que existió una prevalencia de desnutrición crónica, global y aguda de 35,91 %, 8,98 % y 2,32 % respectivamente, con un riesgo de sobrepeso de 19,81 %, sobrepeso de 3,72 % y obesidad de 0,93 %. Estos datos fueron más críticos para los niños con un 40,48 % frente al 31,11 % de desnutrición crónica, con un 10,27 % frente al 7,62 % de desnutrición global, con un 2,11 % frente al 2,54 % de desnutrición aguda en las niñas, con un riesgo de sobrepeso similar de 19,94 % frente al 19,68 % de las niñas, y con un sobrepeso y obesidad mayor en niños de 5,44 % frente al 3,81 % de las niñas. CONCLUSIÓN: Los resultados del estado nutricional muestran que el riesgo de desnutrición en la población de los centros de desarrollo infantil estuvo por encima de los promedios nacionales: 10,6 % mayor en desnutrición crónica (25,3 %), 2,6 % mayor en desnutrición global (6,4 %) y relativamente igual en desnutrición aguda (2,4 %). En sobrepeso y obesidad, 4,0 % menor a los datos de la Encuesta Nacional de Salud y Nutrición en 2012 (8,6 %), aunque los datos hacen referencia a niños menores de cinco años

OBJECTIVE: The aim of this study was to assess nutritionalstatus of children from one to three years of age in child development centers in the parish of Calderon. Materials and methods: Descriptive cross-sectionalstudy in 646 children from one to three years old who regularly attend twenty child development centers in the parish of Calderón, city of Quito. 51,2% boys and 48,8% girls were evaluated. As time dimension, a study between May toSeptember 2019 was conducted. The variables described in the study were average and standard deviation with a comparative analysis by gender. A correlational analysis was subsequently executed applying Chi Square analysis, one-way ANOVA, and two-way ANOVA for independent data, as well as the 95% CI. RESULTS: It was determined that there was a prevalence of chronic, global, and acute malnutrition of 35,91%, 8,98%, and 2,32% respectively, with a risk of overweight of 19,81%, overweight of 3,72% and 0,93% obesity. These data were more critical for children with 40,48% compared to 31,11% of chronic malnutrition, 10,27% compared to 7,62% of global malnutrition, 2,11% compared to 2,54% of acute malnutrition in girls, with a similar risk of overweight of 19,94% compared to 19,68% of girls, and a higher overweight and obesity in boys of 5,44% compared to 3,81% of girls. On the other hand, there is a relationship between gender and chronic malnutrition; body mass index and acute malnutrition; and an interaction between gender and overall malnutrition on weight, gender, and chronic malnutrition on height; and gender and acute malnutrition on body mass index. CONCLUSION: The results of the nutritional status show that the risk of malnutrition in the population of child development centers was above the prevalence of national reports: 10,6% higher in chronic malnutrition (25,3%), 2,6 % higher in global malnutrition (6,4%) and relatively equal in acute malnutrition(2,4%). In terms of overweight and obesity 4,0% lower than the data collected from the National Health and Nutrition Survey in 2012 (8,6%) although the data refer to children under five years of age

Factors Associated with Stunting among Children under 5 Years in Five South Asian Countries (2014-2018): Analysis of Demographic Health Surveys.

South Asia continues to be the global hub for child undernutrition with 35% of children still stunted in 2017. This paper aimed to identify factors associated with stunting among children aged 0-23 months, 24-59 months, and 0-59 months in South Asia. A weighted sample of 564,518 children aged 0-59 months from the most recent Demographic and Health Surveys (2014-2018) was combined of five countries in South Asia. Multiple logistic regression analyses that adjusted for clustering and sampling weights were used to examine associated factors. The common factors associated with stunting in three age groups were mothers with no schooling ([adjusted odds ratio (AOR) for 0-23 months = 1.65; 95% CI: (1.29, 2.13)]; [AOR for 24-59 months = AOR = 1.46; 95% CI: (1.27, 1. 69)] and [AOR for 0-59 months = AOR = 1.59; 95% CI: (1.34, 1. 88)]) and maternal short stature (height < 150 cm) ([AOR for 0-23 months = 2.00; 95% CI: (1.51, 2.65)]; [AOR for 24-59 months = 3.63; 95% CI: (2.87, 4.60)] and [AOR for 0-59 months = 2.87; 95% CI: (2.37, 3.48)]). Study findings suggest the need for a balanced and integrated nutrition strategy that incorporates nutrition-specific and nutrition-sensitive interventions with an increased focus on interventions for children aged 24-59 months.

Assessment of the nutritional status of 6-36-month-old infants in Xinjiang and analysis of the influencing factors.

The health of infants is not only related to family happiness, but also to the future and development of the country. Therefore, it is still a very important public health problem to pay attention to the nutritional health level of infants. This article explores the nutritional health levels of infants and reveals the related risk factors. Stratified and multi-stage cluster sampling was used to select 3949 infants and young children in Xinjiang for the study. Survey staff conducted face-to-face questionnaire surveys to investigate their demographic characteristics, complementary food feeding, and related risk factors affecting their nutritional status. Study results showed that compared with the Han nationality, the Uygur and other nationalities were independent risk factors for malnutrition, as odds ratio (OR) values were 2.456 and 1.747, respectively (P < 0.05). When the feeders were not maternal, and their educational background was junior high school or below, OR values were 2.122 and 1.810, respectively (P < 0.05). The scores for non-breastfeeding and feeding behaviors were independent risk factors, and OR values were 1.983 and 2.709, respectively (P < 0.05). When infant minimum dietary diversity, minimum meal frequency, and minimum acceptable diet were unqualified, these indices were independent risk factors, and OR values were 2.281, 2.315, and 1.865, respectively (P < 0.05). The healthy growth of Han infants is better than that of other ethnic groups, which may be related to varying living environments, customs, social/economic development levels, educational levels, and other factors. In the future, the focus of our work should be to cooperate with the superior health organization to strengthen and improve the nutritional health level of infants.

Nearly one in three children is suffering from sub-optimal feeding practice in Gibe District, Hadiya zone, South Ethiopia.

BACKGROUND: Although infant and young child feeding practices play an important role, children in Ethiopia suffer from poor infant and young child feeding. To date, there is a limited study which addresses factors that influence infant and young child feeding practices. The aim of the study was to determine the predictors of infant and young child feeding practices in Gibe District, Hadiya Zone, Ethiopia. METHODS: A community-based cross-sectional study was employed on 418 randomly selected mothers with children under the age of 24 months from March 13 to April 13, 2017. The pre-tested structured questionnaire was used to collect the data. Multiple logistic regressions were applied to determine the predictors of infant and young child feeding practices. RESULTS: A total of 284 (67.9%) infant and young child suffered from the sub-optimal infant and young child feeding practices. The husband being a government employee [adjusted odds ratio (AOR) = 4.08 (1.65, 10.04)], lower household income [(AOR) = 3.11 (1.36, 7.07)], not attending antenatal care (AOR = 2.03 (1.22, 3.36)], child age 0-5 months [AOR = 2.42 (1.02, 5.72)], negative attitude towards infant and young child feeding practices [AOR = 2.35 (1.44, 3.84)], and the number of children 3-4 [AOR = 1.99 (1.08, 3.64)] were predictors of the sub-optimal infant and young child feeding practices. CONCLUSION: Sub-optimal infant and young child feeding practices were very high as compared to the WHO infant and child feeding recommendation. The husband being a government employee, lower household income, not attending antenatal care, child age 0-5 months, negative attitude towards infant and young child feeding practices, and the number of children 3-4 were the predictors of the sub-optimal infant and young child feeding practices. Nutritional interventions should emphasize the predictors of sub-optimal infant and young child feeding practices to improve optimal infant and young child feeding practices in Ethiopia.

Nutrition gap in children, urban-rural: the key education and food. Colombia, 2015.

OBJECTIVE: To analyze the nutritional situation of children under five years old from both urban and rural areas of Colombia. METHOD: Analytical study, based on cross-sectional data, collected from ENSIN-2015. The sample consisted of 12,256 children aged between 0 and 4 years old. We calculated the prevalence ratios (PR) with their respective 95% confidence interval (95%CI). PR were assessed by binomial regression models with malnutrition or overweight as the dependent variable and geographic area as the explanatory variable. We used context variables to adjust the estimated PR and control the confounder within. RESULTS: Acute malnutrition (weight-for-height) had a prevalence of 1.6%, while overweight had a 5.6% rate. No differences per geographic zone in the weight-for-height indicator were found. Stunted growth - chronic malnutrition - was higher in the rural area (PR = 1.2; 95%CI 1-1.53; p = 0.050). Prevalences adjusted by variables related to structural, social and economic developement showed that both the household chief's educational level and the food insecurity of the area account for malnutrition. CONCLUSION: The height-for-age indicator works better to establish development level. Measures against coverage, relevance and quality of education and access to food can harm the nutritional status of the children.

Micronutrient deficiencies in pediatric short bowel syndrome: a 10-year review from an intestinal rehabilitation center in China.

PURPOSE: Vitamins and trace elements are essential nutrients for growth and intestinal adaptation in children with short bowel syndrome (SBS). This study aimed to assess micronutrients' status during and after weaning off PN in pediatric SBS. METHODS: This retrospective study evaluated the follow-up of 31 children with SBS between Jan 2010 and Sep 2019. Clinical data were reviewed from the patients' electric medical record. Serum electrolytes, trace elements, vitamin B12, vitamin D, and folate concentrations were collected before and after enteral autonomy. RESULTS: Thirty-one SBS cases were reviewed (median onset age 11 days after birth, 51.6% boys, mean PN duration 4 months, and mean residual small intestine length 58.2 cm). Median duration of follow-up was 10 months (interquartile range [IQR]: 4, 19). The common micronutrient deficiencies were zinc (51.6%), copper (38.7%), vitamin D (32.3%), and phosphorus (25.8%) after the transition to EN. The proportion of patients deficient in vitamin D decreased dramatically from 93.5% to 32.3% (P < 0.001), and serum concentrations of vitamin D increased significantly (27.4 ± 12.3 vs. 60.3 ± 32.9 nmol/l, P = 0.03) after achieving full enteral feeding more than 1 month. Additionally, serum magnesium levels significantly increased (0.76 ± 0.17 vs. 0.88 ± 0.14 mmol/l, P = 0.03). Hemoglobin levels elevated significantly after weaning off PN (104.3 ± 10.7 vs. 117.8 ± 13.7 g/l, P = 0.03). CONCLUSIONS: Micronutrient deficiencies remain a common problem in pediatric SBS through intestinal rehabilitation. Therefore, we strongly recommend supplementation of more vitamin D and trace elements (zinc, copper, and phosphorus) under regular monitoring during long-term intestinal rehabilitation.

Neurodevelopmental outcomes of preterm babies during infancy in Eastern Uganda: a prospective cohort study.

BACKGROUND: Complications due to prematurity are a threat to child survival and full developmental potential particularly in low-income settings. OBJECTIVE: The aim of the study was to determine the neurodevelopmental outcomes among preterm infants and identify any modifiable factors associated with neurodevelopmental disability (NDD). METHODS: We recruited 454 babies (242 preterms with birth weight <2.5 kg, and 212 term babies) in a cohort study at birth from Iganga hospital between May and July 2018. We followed up the babies at an average age of 7 months (adjusted for prematurity) and assessed 211 preterm and 187 term infants for neurodevelopmental outcomes using the Malawi Developmental Assessment tool. Mothers were interviewed on care practices for the infants. Data were analyzed using STATA version 14. RESULTS: The study revealed a high incidence of NDD of 20.4% (43/211) among preterm infants compared to 7.5% (14/187) among the term babies, p < 0.001, of the same age. The most affected domain was fine motor (11.8%), followed by language (9.0%). At multivariate analysis, malnutrition and Kangaroo Mother Care (KMC) at home after discharge were the key factors that were significantly associated with NDD among preterm babies. The prevalence of malnutrition among preterm infants was 20% and this significantly increased the odds of developing NDD, OR = 2.92 (95% CI: 1.27-6.71). KMC practice at home reduced the odds of developing NDD, OR = 0.46, (95% CI: 0.21-1.00). Re-admission of preterm infants after discharge (a sign of severe illness) increased the odds of developing NDD but this was not statistically significant, OR = 2.33 (95% CI: 0.91-5.94). CONCLUSION: Our study has shown that preterm infants are at a high risk of developing NDD, especially those with malnutrition. Health system readiness should be improved to provide follow-up care with emphasis on improving nutrition and continuity of KMC at home.

[Mortality pattern in children aged 3-59 months hospitalized in the Intensive Care Unit at a Paediatric Center in Yaounde-Cameroon]. / Profil des décès survenus chez les enfants âgés de 3 à 59 mois dans l'unité des soins intensifs d'un centre pédiatrique à Yaoundé-Cameroun.

INTRODUCTION: mortality risk is high at the Intensive Care Units (ICU) in developing countries. We here report the deaths occurred in the ICU at the Mother and Child Center in Yaounde, Cameroon. METHODS: we conducted a retrospective study on the clinical, socio-demographic features, the therapeutic strategy as well as some of the factors associated with deaths occurred in 200 patients aged 3-59 months between 2010 and 2014. RESULTS: out of 2675 patients included in the study, 1807 were aged 3-59 months and 303 died. The overall and cause-specific mortality rate in this age group was 11.3% and 16.7% respectively. Most patients (152/200; 76.0%) died within 24 months and the median admission time was 7 days. More than half of patients (57.0%) presented to a health center and only 66 (33.0%) presented to a referral hospital. Severe malaria (41.5%), pneumonia (22.7%) and gastroenteritis (27.8%) were the most common diseases. Malnutrition and HIV/AIDS were the underlying causes of death in 23.0% and 20.5% of patients respectively. Gastroenteritis multiplied the risk of death of approximately 6 times (OR = 5.76; p = 0.000) in patients affected by malnutrition and HIV infection. Deaths mainly occurred (90.0%) within 72 hours of admission. CONCLUSION: despite limited resources, some diseases could have been easily treated avoiding complications which require reanimation. It is essential to intensify the fight against malaria, HIV infection and malnutrition.

Defining diet quality: a synthesis of dietary quality metrics and their validity for the double burden of malnutrition.

Achieving most of the UN Sustainable Development Goals requires a strong focus on addressing the double burden of malnutrition, which includes both diet-related maternal and child health (MCH) and non-communicable diseases (NCDs). Although, the most optimal dietary metric for assessing malnutrition remains unclear. Our aim was to review available global dietary quality metrics (hereafter referred to as dietary metrics) and evidence for their validity to assess MCH and NCD outcomes, both separately and together. A systematic search of PubMed was done to identify meta-analyses or narrative reviews evaluating validity of diet metrics in relation to nutrient adequacy or health outcomes. We identified seven dietary metrics aiming to address MCH and 12 for NCDs, no dietary metrics addressed both together. Four NCD dietary metrics (Mediterranean Diet Score, Alternative Healthy Eating Index, Healthy Eating Index, and Dietary Approaches to Stop Hypertension) had convincing evidence of protective associations with specific NCD outcomes, mainly mortality, cardiovascular disease, type 2 diabetes, and total cancer. The remaining NCD dietary metrics and all MCH dietary metrics were not convincingly validated against MCH or NCD health outcomes. None of the dietary metrics had been validated against both MCH and NCD outcomes. These findings highlight major gaps in assessing and addressing diet to achieve global targets and effective policy action.